In the cell nucleus, only a small fraction of DNA is accessible to DNA-binding proteins. These open regions of DNA can reveal a lot of information about the state of a cell. Understanding how the regulatory landscape controls gene expression in individual cells is fundamental to the study of biology. The Chromium Single Cell ATAC Solution (scATAC-seq) is a powerful epigenomic tool to map chromatin accessibility and to analyze transcriptional regulatory mechanisms at single cell resolution.
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